| # | Gebäude | Bilder | Höhe | Etagen | Gebäudetyp | Jahr | Status |
|---|---|---|---|---|---|---|---|
| 1 | The District - Tower II | 631 ft | - | Wolkenkratzer | 2022 | ||
| 2 | The District - Tower I | 544 ft | - | Wolkenkratzer | 2022 | ||
| 3 | Methodist Outpatient Care Center | 31 | 512 ft | 26 | Wolkenkratzer | 2010 | |
| 4 | The O'Quinn Medical Tower at St. Luke's | 15 | 477 ft | 29 | Wolkenkratzer | 1990 | |
| 5 | Lester and Sue Smith Legacy Tower | 5 | 457 ft | 25 | Wolkenkratzer | 2013 | |
| 6 | Memorial Hermann Medical Plaza | 32 | 430 ft | 28 | Wolkenkratzer | 2007 | |
| 7 | The Spires | 4 | 427 ft | 40 | Wolkenkratzer | 1983 | |
| 8 | The Spires II | 426 ft | 40 | Wolkenkratzer | - | ||
| 9 | M.D. Anderson Cancer Center - Mid-Campus Building One | 29 | 415 ft | 25 | Wolkenkratzer | 2012 | |
| 10 | The Parklane | 6 | 390 ft | 36 | Wolkenkratzer | 1983 | |
| 11 | Susan and Fayez Sarofim Pavilion | 380 ft | 15 | Wolkenkratzer | 2019 | ||
| 12 | X Houston | 370 ft | 33 | Wolkenkratzer | 2022 | ||
| 13 | Smith Tower | 1 | 367 ft | 26 | Wolkenkratzer | 1988 | |
| 14 | Warwick Towers | 10 | 361 ft | 30 | Wolkenkratzer | 1983 | |
| 15 | Hanover Hermann Park | 18 | 358 ft | 29 | Wolkenkratzer | 2009 | |
| 16 | Mosaic on Hermann Park | 20 | 358 ft | 29 | Wolkenkratzer | 2007 | |
| 17 | 3300 Main | 5 | 351 ft | 29 | Wolkenkratzer | 2020 | |
| 18 | TCH West Tower | 5 | 348 ft | 20 | Wolkenkratzer | 2001 | |
| 19 | University Center Tower | 2 | 345 ft | 25 | Wolkenkratzer | 1974 | |
| 20 | Drewery Place | 2 | 328 ft | 28 | Hochhaus | 2019 |