| # | Gebäude | Bilder | Höhe | Etagen | Gebäudetyp | Jahr | Status |
|---|---|---|---|---|---|---|---|
| 21 | Oliver Building | 15 | 347 ft | 25 | Wolkenkratzer | 1910 | |
| 22 | Farmers Bank Building | 345 ft | 27 | Wolkenkratzer | 1902 | ||
| 23 | Three Gateway Center | 7 | 344 ft | 24 | Wolkenkratzer | 1952 | |
| 24 | Centre City Tower | 3 | 341 ft | 26 | Wolkenkratzer | 1971 | |
| 25 | William S. Moorhead Federal Building | 7 | 340 ft | 23 | Wolkenkratzer | 1964 | |
| 26 | Verizon Building | 3 | 339 ft | 21 | Wolkenkratzer | 1931 | |
| 27 | Wyndham Grand Pittsburgh Downtown | 10 | 333 ft | 22 | Wolkenkratzer | 1959 | |
| 28 | Frick Building | 10 | 330 ft | 20 | Wolkenkratzer | 1902 | |
| 29 | Four Gateway Center | 9 | 305 ft | 22 | Hochhaus | 1960 | |
| 30 | Washington Plaza | 1 | 300 ft | 24 | Hochhaus | 1964 | |
| 31 | Commonwealth Building | 6 | 300 ft | 21 | Hochhaus | 1906 | |
| 32 | AT&T Building | 7 | 280 ft | 16 | Hochhaus | 1969 | |
| 33 | One Gateway Center | 2 | 276 ft | 20 | Hochhaus | 1952 | |
| 34 | Two Gateway Center | 4 | 276 ft | 20 | Hochhaus | 1952 | |
| 35 | Allegheny County Courthouse | 23 | 250 ft | 5 | Gebäude mit Türmen | 1888 | |
| 36 | Union Trust Building | 9 | 237 ft | 15 | Hochhaus | 1917 | |
| 37 | Six PPG Place | 3 | 223 ft | 14 | Hochhaus | 1984 | |
| 38 | DoubleTree Hotel Pittsburgh | 3 | 218 ft | 20 | Hochhaus | 1951 | |
| 39 | 151 First Side | 1 | 216 ft | 18 | Hochhaus | 2007 | |
| 40 | Trinity Episcopal Cathedral | 1 | 200 ft | - | Kirche | 1872 |