| # | Gebäude | Bilder | Höhe | Etagen | Gebäudetyp | Jahr | Status |
|---|---|---|---|---|---|---|---|
| 41 | Hyatt Regency Buffalo | 6 | ≈213 ft | 16 | Hochhaus | 1923 | |
| 42 | City Centre Condominiums | 3 | ≈187 ft | 14 | Hochhaus | 1927 | |
| 43 | Chamber of Commerce Building | ≈173 ft | 13 | Hochhaus | 1907 | ||
| 44 | Guaranty Building | 9 | ≈173 ft | 13 | Hochhaus | 1896 | |
| 45 | Key Center - South Tower | 4 | ≈173 ft | 13 | Hochhaus | 1990 | |
| 46 | M & T Center | 2 | ≈160 ft | 12 | Hochhaus | 1985 | |
| 47 | Buffalo Athletic Club | 3 | ≈160 ft | 12 | Hochhaus | 1922 | |
| 48 | Hotel Buffalo | ≈160 ft | 12 | Hochhaus | 1908 | ||
| 49 | The Flagstaff | ≈160 ft | 12 | Hochhaus | 1952 | ||
| 50 | The Gulfstream | ≈160 ft | 12 | Hochhaus | 1952 | ||
| 51 | The Ebbtide | ≈160 ft | 12 | Hochhaus | 1952 | ||
| 52 | The Driftwood | ≈160 ft | 12 | Hochhaus | 1952 | ||
| 53 | The Coastline | ≈160 ft | 12 | Hochhaus | 1952 | ||
| 54 | The Admiral | ≈160 ft | 12 | Hochhaus | 1952 | ||
| 55 | Convention Tower | 3 | ≈160 ft | 12 | Hochhaus | 1924 | |
| 56 | A. Victor & Company Department Store | ≈147 ft | 11 | Hochhaus | 1928 | ||
| 57 | Cathedral Park Tower | 2 | 11 | Flachbau | 1915 | ||
| 58 | Hyatt Regency Buffalo Addition | ≈133 ft | 10 | Hochhaus | 1984 | ||
| 59 | Hotel Worth Addition | ≈133 ft | 10 | Flachbau | 1926 | ||
| 60 | Lafayette Building | ≈133 ft | 10 | Hochhaus | 1922 |